Intravenous -artemether formulation (ARM NLC) as a superior alternative to commercial artesunate formulation

Disposition of 5-fluorouracil after intravenous bolus doses of a commercial formulation to cancer patients.

A high-pressure liquid chromatographic method that is used to determine the pharmacokinetic disposition of 5-fluorouracil from the plasma compartment is presented. The method requires only 0.5 ml of plasma for each determination and is sensitive to 0.1 mg of drug per liter. Novel methodology with the use of an ion-specific electrode technique for the determination of urinary excretion kinetics ...

Safety of an intravenous formulation of lamotrigine

PURPOSE Intravenous (IV) formulations are useful when treating patients where oral administration is not possible and to study certain pharmacokinetic parameters such as bioavailability. We developed a stable-labeled IV formulation of lamotrigine (LTG) for studying pharmacokinetics in epilepsy patients. METHODS Stable-labeled IV LTG was given to 20 persons with epilepsy (6 men; 14 women) with...

Acetaminophen Analysis in Different Commercial Formulation of Iranian Acetaminophen Tablets

Acetaminophen is one of the most important antipyretic and analgesic drugs. It has an excellent efficacy when it's used in therapeutic doses, but in unsafe doses it can be resulted in hepatotoxicity and permanent liver failure. Due to disparities that have been reported between the actual and stated concentration of acetaminophen tablets, we aimed to compare the actual quantity of 8 Iranian gen...

An alternative formulation of classical electromagnetic duality

By introducing a doublet of electromagnetic four dimensional vector potentials, we set up a manifestly Lorentz covariant and SO(2) duality invariant classical field theory of electric and magnetic charges. In our formulation one does not need to introduce the concept of Dirac string.

Optimization of Nanostructured Lipid Carrier (NLC) Formulation: Selecting the Appropriate Parameters and Components for Optimized Drug Delivery System Formulation